The most important thing to remember here is that the points should total up to 125. Its also worth noting that unlike a wolf, bear, or eagle, this creature is monstrous, and will be reacted to as such -- a wolf may draw calls to animal control, but a monster will generate even more extreme reactions.
Basic Man-Monster 
ST +2, DX +2, HT +2, Speed +.5, Teeth (sharp), Claws (sharp), Night vision 5, Damage Resistance 4 (tough skin), fur, Social Stigma (Monster), Ham-fisted, spoken language drops to accented, 32 point animal lens
were-men tend to have a lot of similarities: Teeth, claws, fur, and an animalistic fury. They're bodies are pretty much in a monster shape rather than an animal form, and the focus is really on building a monster, not an animal. The spoken language at accented reflects an appropriate animal voice, and while it doesn't drive people away (your looks already do that, and you can turn it off whenever they want) it can make it difficult to communicate with teammates.
Because we retain the human shape, a lot of the statistics are lower. But we keep fine manual dexterity, which means the character can use weapons and open doors freely. These types of monsters are made to use weapons, be they guns, blades, or something more exotic, and that can make these things terrifying. Night vision 5 is the higher than any of the natural animal templates. Once again, this is because this creature really isn't half-man half-animal, but a monster.
The remaining points spent on a combination of senses and movement abilities, flavored for the appropriate animal. While these abilities are only about a quarter of the point total, they keep the monster tied to its animal roots.
Animal Lenses 
Wolf-man: Acute hearing 3, Enhanced Move (ground) .5, Discriminatory Smell, Penetrating voice
Cat-man: Acute Smell 1 , Perfect Balance, Discriminatory Hearing
Rat-man: Discriminatory smell, Perfect Balance, Night vision raised to 7
Other animals are quite possible, and should be appropriately themed. Smaller animals are particularly appropriate, as they can be made into a monster capable of making up for the animals natural small size.
More than one Template
Adding another template to a were is an additional 27 points. This is a big investment, but its also a very powerful one, giving a very different set of capabilities to the lycanthrope. The template taken should almost always be an intermediate or completed form of the creature. The lycanthrope should also specify which form is reverted to during the full moon.
As a Monster
ST 20 HP 20 Speed: 8.25
DX 15 Will 12 Move: 8
IQ 5 Per 13 Weight: 150-200
HT 16 FP 16 SM: 0
Dodge: 12 DR 6 (tough skin)
bite (15): 2d-2 cut, reach C, -1 to defense
claw (15): 2d-2 cut, reach C, -1 to defense
Improvised Club (14) 4d+1/2d+1 cr, reach 1
Its worth noting this sort of Lycanthrope is weaker than the classic forms -- unless it can get its hands on something. This monster is more dangerous in an urban or semi-urban enviroment than in the wilderness proper. Although the IQ is low, these monsters are quite willing to pick up an object and beat their foe with it.
This sort of were is most dangerous as the semi-rational or rational head of a larger pack -- one with multiple forms, and who has combined human and animal into a single monstrous form using the benefits of both. While all weres are more dangerous in this form, half-men get particularly more dangerous, as they are able to take full advantage of weapons.